One of the greatest statements that ever fell from the lips of the Lord Jesus Christ is "For whoever wishes to save his life shall lose it, but whoever loses his life for My sake shall find it, for what will a man be profited if he gains the whole world and forfeits his soul or what will a man give in exchange for his soul?"
Jesus was talking about an exchange. He was talking about losing something to gain something. What He said was that in order for you to gain you would have to lose your life. If you want to gain your soul it will cost you your life. If you desire to save your life, it will cost you your soul. In other words, if you hold on to the things that to you are precious and reject the things that to God are precious, it will cost you your eternal soul. That's the exchange. And Jesus said, "What good is it if you have gained everything the world has to offer and lost your eternal soul?" You would be much better off to make some exchange of what you have in this life for what God offers you in the life to come. Whatever exchange you need to make to gain your eternal soul, you ought to do that. That's a very significant spiritual principle.
There is an exchange in salvation. There is an exchange of all that I am for all that Christ is. Whatever it is that I have spent my life accumulating, even if I gain the world, it would mean nothing if I lost Christ. So I will exchange it all for Him. That's what Jesus is saying. The wise person looks at everything in life, measures it against the value of the loss of his eternal soul and says it isn't worth it, I will give this up to gain my eternal soul.